2'-Fluoro-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C10H12FN5O4
- 分子量
- 285.23
- 纯度
- >=98% (HPLC)
2'-Fluoro-2'-deoxyguanosine (2'-F-dG) is a guanosine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64027 is identified by CAS 78842-13-4, molecular formula C10H12FN5O4, molecular weight 285.23, and PubChem CID 135415565.
The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64027 provides the guanosine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.
同义词
2'-Fluoro-2'-deoxyguanosine; 2'-F-dG; 2'-F-G
身份与规格
| Catalog No. | CH64027 |
| CAS No. | 78842-13-4 |
| Molecular Formula | C10H12FN5O4 |
| Molecular Weight | 285.23 |
| PubChem CID | 135415565 |
| InChIKey | UXUZARPLRQRNNX-DXTOWSMRSA-N |
| Purity | >=98% (HPLC) |
储存条件
0-10 C
技术属性
- Nucleobase
- Guanine
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Nucleoside class
- 2'-Fluoro purine nucleoside
- Packaging
- 1 g; 2 g; 5 g; 10 g; 200 mg and 1 g glass bottles with plastic inserts; Custom packaging on request
- Physical form
- Solid; white to light yellow powder to crystal
应用背景
- 2'-F oligonucleotide research: CH64027 is relevant to siRNA and antisense modification studies involving 2'-fluoro guanosine residues.
- Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
- 2'-F nucleoside reference: CH64027 provides the 2'-fluoro-2'-deoxyguanosine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 135415565
PubChem · CID 135415565
常见问题
How is 2'-F-dG different from 2'-deoxyguanosine?
2'-Deoxyguanosine has a hydrogen at the 2' position; 2'-fluoro-2'-deoxyguanosine has a fluorine there. 2'-deoxyguanosine is cataloged separately.
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