2'-O-(2-Methoxyethyl)-5-methyluridine
1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 化学名称
- 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
- 分子式
- C13H20N2O7
- 分子量
- 316.31
- 纯度
- >=98%
2'-O-(2-Methoxyethyl)-5-methyluridine (2'-O-MOE-5-Me-U), also called 2'-O-MOE ribothymidine, is 5-methyluridine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64032 is identified by CAS 163759-49-7, molecular formula C13H20N2O7, molecular weight 316.31, and PubChem CID 11243988.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64032 provides the 2'-O-MOE-5-methyluridine identity for related antisense-oligonucleotide research.
同义词
2'-O-(2-Methoxyethyl)-5-methyluridine; 2'-O-MOE-5-Me-U; 2'-O-MOE-ribothymidine
身份与规格
| Catalog No. | CH64032 |
| CAS No. | 163759-49-7 |
| Molecular Formula | C13H20N2O7 |
| Molecular Weight | 316.31 |
| PubChem CID | 11243988 |
| InChIKey | NEVQCHBUJFYGQO-DNRKLUKYSA-N |
| Purity | >=98% |
储存条件
2-8 C
技术属性
- Nucleobase
- 5-Methyluracil
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- Custom packaging on request
- Physical form
- White to off-white powder
应用背景
- MOE gapmer antisense research: CH64032 is relevant to gapmer antisense studies involving 2'-O-MOE 5-methyl-U residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64032 provides the 2'-O-(2-methoxyethyl)-5-methyluridine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 11243988
PubChem · CID 11243988
常见问题
What nucleobase does CH64032 contain?
CH64032 is a 5-methyluridine derivative: it has a 5-methyluracil base and a 2'-O-(2-methoxyethyl) ribose modification.
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