2'-O-(2-Methoxyethyl)cytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C12H19N3O6
- 分子量
- 301.30
- 纯度
- >98.0% (HPLC, titration)
2'-O-(2-Methoxyethyl)cytidine (2'-O-MOE-C) is cytidine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64033 is identified by CAS 223777-16-0, molecular formula C12H19N3O6, molecular weight 301.30, and PubChem CID 11077469.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64033 provides the cytidine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.
同义词
2'-O-(2-Methoxyethyl)cytidine; 2'-O-MOE-C; 2'-MOE-C
身份与规格
| Catalog No. | CH64033 |
| CAS No. | 223777-16-0 |
| Molecular Formula | C12H19N3O6 |
| Molecular Weight | 301.30 |
| PubChem CID | 11077469 |
| InChIKey | YKOGMMXZKKVMBT-QCNRFFRDSA-N |
| Purity | >98.0% (HPLC, titration) |
储存条件
0-10 C
技术属性
- Nucleobase
- Cytosine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- 200 mg; 1 g; Custom packaging on request
- Physical form
- Solid; white to yellow powder to crystal
应用背景
- MOE gapmer antisense research: CH64033 is relevant to gapmer antisense studies involving 2'-O-MOE cytidine residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- 2'-O-MOE nucleoside reference: CH64033 provides the 2'-O-(2-methoxyethyl)cytidine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 11077469
PubChem · CID 11077469
常见问题
How is 2'-O-MOE-cytidine different from 2'-O-methylcytidine?
Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methylcytidine is cataloged separately.
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