Oligonucleotide Synthesis, RNA Raw Materials & Modification

7-Deaza-2'-deoxyadenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64045CAS号60129-59-1纯度>98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C11H14N4O3
分子量: 250.25
纯度: >98%

7-Deaza-2'-deoxyadenosine, also called 2'-deoxytubercidin (c7dA), is 2'-deoxyadenosine in which the purine N7 nitrogen is replaced by carbon, giving a pyrrolo[2,3-d]pyrimidine base. CH64045 is identified by CAS 60129-59-1, molecular formula C11H14N4O3, molecular weight 250.25, and PubChem CID 3006222.

The cited oligonucleotide literature discusses 7-deaza-dA analogs in base-pairing, metal-mediated base-pair, and duplex-stability studies where the N7 position is being examined. CH64045 provides the 7-deaza-2'-deoxyadenosine identity for related base-analog research.

同义词

7-Deaza-2'-deoxyadenosine; 2'-deoxytubercidin; c7dA; 7-deaza-dA

身份与规格

Catalog No.	CH64045
CAS No.	60129-59-1
Molecular Formula	C11H14N4O3
Molecular Weight	250.25
PubChem CID	3006222
InChIKey	NIJSNUNKSPLDTO-DJLDLDEBSA-N
Purity	>98%

储存条件

2-8 C; keep dark and dry

技术属性

Nucleobase analog: 7-Deazaadenine
Sugar: 2'-Deoxyribose
Base modification: 7-Deaza (N7 replaced by carbon)
Research role: Modified-oligonucleotide building-block reference
Packaging: 500 mg; 1 g; 10 g; 25 g; 50 g; 100 g; Custom packaging on request
Physical form: White to off-white powder

应用背景

7-Deazapurine oligonucleotide research: CH64045 is relevant to base-pairing, metal-mediated base-pair, and duplex-stability studies involving the N7→C base modification.
N7-position interaction studies: the 7-deaza base helps compare DNA systems where Hoogsteen or metal-binding behavior at the purine N7 position is being evaluated.
Base-analog reference: CH64045 provides the 7-deaza-2'-deoxyadenosine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 3006222
PubChem · CID 3006222

常见问题

What is different about 7-deaza-2'-deoxyadenosine?

The purine N7 nitrogen is replaced by carbon, forming a 7-deazapurine / pyrrolo[2,3-d]pyrimidine base. This removes the N7 site considered in Hoogsteen and metal-binding studies.