7-Deaza-7-Iodo-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C11H13IN4O3
- 分子量
- 376.15
- 纯度
- >98.0% (HPLC)
7-Deaza-7-Iodo-2'-deoxyadenosine is 7-deaza-2'-deoxyadenosine carrying an iodine at the C7 position of the pyrrolo[2,3-d]pyrimidine base. CH64048 is identified by CAS 166247-63-8, molecular formula C11H13IN4O3, molecular weight 376.15, PubChem CID 15289165, and InChIKey LIIIRHQRQZIIRT-XLPZGREQSA-N.
In the cited 7-deazapurine literature, the C7-halogen position is discussed as a functionalization point for palladium cross-coupling reactions such as Sonogashira or Suzuki coupling. CH64048 provides the 7-deaza-7-iodo-dA identity for C7-functionalized oligonucleotide research.
同义词
7-Deaza-7-iodo-2'-deoxyadenosine; 7-iodo-c7dA
身份与规格
| Catalog No. | CH64048 |
| CAS No. | 166247-63-8 |
| Molecular Formula | C11H13IN4O3 |
| Molecular Weight | 376.15 |
| PubChem CID | 15289165 |
| InChIKey | LIIIRHQRQZIIRT-XLPZGREQSA-N |
| Purity | >98.0% (HPLC) |
储存条件
Room temperature; recommended <15 C, cool and dark, under inert gas; air sensitive
技术属性
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- Base modification
- 7-Deaza
- C7 substituent
- Iodo cross-coupling handle
- Packaging
- 200 mg; 500 mg; Custom packaging on request
- Physical form
- White to light yellow powder to crystal; solid at 20 C
应用背景
- C7 cross-coupling research: the C7-iodine on the 7-deazapurine base is relevant to Sonogashira/Suzuki-style functionalization studies for C7-modified oligonucleotides.
- Modified-DNA studies: CH64048 combines the N7-removed 7-deazapurine scaffold with a C7 halogen position for base-analog research.
- Base-analog reference: CH64048 provides the 7-deaza-7-iodo-2'-deoxyadenosine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 15289165
PubChem · CID 15289165
常见问题
How is this different from 7-deaza-2'-deoxyadenosine?
It is 7-deaza-2'-deoxyadenosine with an added iodine at C7. The plain 7-deaza-dA is listed separately by CHEMOS.
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