Oligonucleotide Synthesis, RNA Raw Materials & Modification

7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64049CAS号114748-68-4纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C16H16F3N5O4
分子量: 399.32
纯度: >=98%

7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine is a 2',3'-dideoxy 7-deazaguanosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64049 is identified by CAS 114748-68-4, molecular formula C16H16F3N5O4, molecular weight 399.32, PubChem CID 135577907, and InChIKey GMTOEMNRUPBIFY-VHSXEESVSA-N.

The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker, while the 2',3'-dideoxy sugar defines the chain-terminating nucleoside identity. The cited literature discusses amine-linker nucleosides and 7-deazapurine C7 functionalization in fluorescent labeling and DNA-sequencing research.

同义词

7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2',3'-dideoxyguanosine; 7-TFA-ap-c7-ddG

身份与规格

Catalog No.	CH64049
CAS No.	114748-68-4
Molecular Formula	C16H16F3N5O4
Molecular Weight	399.32
PubChem CID	135577907
InChIKey	GMTOEMNRUPBIFY-VHSXEESVSA-N
Purity	>=98%

储存条件

-20 C as powder; -80 C in solvent

技术属性

Nucleobase analog: 7-Deazaguanine
Sugar: 2',3'-Dideoxyribose
C7 linker: 3-Aminoprop-1-ynyl
Amine protection: Trifluoroacetyl (TFA)
Packaging: 100 mg; 500 mg; Custom packaging on request
Physical form: Powder
Stability: 3 years as powder; 1 year in solvent

应用背景

Labeled terminator research: CH64049 combines a 2',3'-dideoxy nucleoside identity with a C7 aminopropynyl linker for DNA-sequencing and labeling studies.
Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
Base-analog reference: CH64049 provides the 7-TFA-ap-7-deaza-2',3'-dideoxyguanosine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 135577907
PubChem · CID 135577907

常见问题

What do 'TFA' and 'ap' mean in the name?

'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.

Why is it a chain terminator?

It is a 2',3'-dideoxynucleoside, which is the sugar pattern associated with chain-terminator designs in DNA-sequencing research. CH64049 also carries a protected C7 amino-linker.