7-TFA-ap-7-Deaza-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C16H16F3N5O4
- 分子量
- 399.32
- 纯度
- >=98%
7-TFA-ap-7-Deaza-2'-deoxyadenosine is a 2'-deoxy 7-deazaadenosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64052 is identified by CAS 178420-75-2, molecular formula C16H16F3N5O4, molecular weight 399.32, PubChem CID 15450746, and InChIKey SVVZRCQYSUXVDB-HBNTYKKESA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. Because the sugar is 2'-deoxy rather than 2',3'-dideoxy, CH64052 is positioned for internal oligonucleotide labeling research rather than chain-terminator designs.
同义词
7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2'-deoxyadenosine; 7-TFA-ap-c7-dA
身份与规格
| Catalog No. | CH64052 |
| CAS No. | 178420-75-2 |
| Molecular Formula | C16H16F3N5O4 |
| Molecular Weight | 399.32 |
| PubChem CID | 15450746 |
| InChIKey | SVVZRCQYSUXVDB-HBNTYKKESA-N |
| Purity | >=98% |
储存条件
4 C, sealed, away from moisture and light
技术属性
- Nucleobase analog
- 7-Deazaadenine
- Sugar
- 2'-Deoxyribose
- C7 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; Custom packaging on request
- Physical form
- Off-white to brown solid powder
- Stability
- 3 years at -20 C or 2 years at 4 C as powder; 6 months at -80 C or 1 month at -20 C in solvent
应用背景
- Internal-labeling research: CH64052 combines a 2'-deoxy nucleoside identity with a C7 aminopropynyl linker for oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64052 provides the 7-TFA-ap-7-deaza-2'-deoxyadenosine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 15450746
PubChem · CID 15450746
常见问题
Is this a chain terminator?
No. It is a 2'-deoxy nucleoside, not a 2',3'-dideoxy nucleoside. The dideoxy version is the chain-terminator design and is listed separately.
What do 'TFA' and 'ap' mean?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
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