Oligonucleotide Synthesis, RNA Raw Materials & Modification

5-TFA-ap-2'-deoxyuridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64053CAS号115899-40-6纯度98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C14H14F3N3O6
分子量: 377.27
纯度: 98%

5-TFA-ap-2'-deoxyuridine is 2'-deoxyuridine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of uracil. CH64053 is identified by CAS 115899-40-6, molecular formula C14H14F3N3O6, molecular weight 377.27, PubChem CID 10894132, and InChIKey HCKMZBZCHQQZRJ-IVZWLZJFSA-N.

The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.

同义词

5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxyuridine; 5-TFA-ap-dU

身份与规格

Catalog No.	CH64053
CAS No.	115899-40-6
Molecular Formula	C14H14F3N3O6
Molecular Weight	377.27
PubChem CID	10894132
InChIKey	HCKMZBZCHQQZRJ-IVZWLZJFSA-N
Purity	98%

储存条件

Room temperature

技术属性

Nucleobase: Uracil
Sugar: 2'-Deoxyribose
C5 linker: 3-Aminoprop-1-ynyl
Amine protection: Trifluoroacetyl (TFA)
Packaging: 100 mg; 250 mg; 1 g; Custom packaging on request

应用背景

Internal-labeling research: CH64053 combines a 2'-deoxyuridine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
Base-analog reference: CH64053 provides the 5-TFA-ap-2'-deoxyuridine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 10894132
PubChem · CID 10894132

常见问题

What do 'TFA' and 'ap' mean in the name?

'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of uracil, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.