Oligonucleotide Synthesis, RNA Raw Materials & Modification

5-TFA-ap-2'-deoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64054CAS号115899-38-2纯度97%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C14H15F3N4O5
分子量: 376.29
纯度: 97%

5-TFA-ap-2'-deoxycytidine is 2'-deoxycytidine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C5 position of cytosine. CH64054 is identified by CAS 115899-38-2, molecular formula C14H15F3N4O5, molecular weight 376.29, PubChem CID 14768553, and InChIKey OKLUSVKQOCPUNW-IVZWLZJFSA-N.

The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.

同义词

5-(3-trifluoroacetamidoprop-1-ynyl)-2'-deoxycytidine; 5-TFA-ap-dC

身份与规格

Catalog No.	CH64054
CAS No.	115899-38-2
Molecular Formula	C14H15F3N4O5
Molecular Weight	376.29
PubChem CID	14768553
InChIKey	OKLUSVKQOCPUNW-IVZWLZJFSA-N
Purity	97%

储存条件

2-8 C, protect from light

技术属性

Nucleobase: Cytosine
Sugar: 2'-Deoxyribose
C5 linker: 3-Aminoprop-1-ynyl
Amine protection: Trifluoroacetyl (TFA)
Packaging: 100 mg; 250 mg; 1 g; 5 g; 25 uL sample solution; Custom packaging on request
Solution concentration: 10 mM supplied sample solution
Physical form: A solid

应用背景

Internal-labeling research: CH64054 combines a 2'-deoxycytidine identity with a C5 aminopropynyl linker for oligonucleotide labeling studies.
Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
Base-analog reference: CH64054 provides the 5-TFA-ap-2'-deoxycytidine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 14768553
PubChem · CID 14768553

常见问题

What do 'TFA' and 'ap' mean in the name?

'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at the C5 position of cytosine, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.