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Oligonucleotide Synthesis, RNA Raw Materials & Modification

5-TFA-aha-2'-deoxyuridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64055CAS号252337-58-9纯度>98.00%
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产品概述

快速信息

产品系列
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C20H27F3N4O7
分子量
492.4
纯度
>98.00%

5-TFA-aha-2'-deoxyuridine is 2'-deoxyuridine carrying a longer amino-linker (the "aha" arm) at the C5 position of uracil, with the linker's terminal amine protected as a trifluoroacetamide (TFA). CH64055 is identified by CAS 252337-58-9, molecular formula C20H27F3N4O7, molecular weight 492.4, PubChem CID 15484914, and InChIKey CSMRZKBUOFUSRQ-JHCHYBNPSA-N.

Compared with the shorter C5 aminopropynyl linker in 5-TFA-ap-2'-deoxyuridine, the larger formula and PubChem structure indicate a longer spacer arm. The cited labeling literature discusses amine-linker nucleosides as motifs for covalent fluorophore attachment in nucleoside and oligonucleotide labeling research.

同义词

5-TFA-aha-dU; 5-[TFA-protected aminohexanoyl-type amino-linker]-2'-deoxyuridine

身份与规格

Catalog No.CH64055
CAS No.252337-58-9
Molecular FormulaC20H27F3N4O7
Molecular Weight492.4
PubChem CID15484914
InChIKeyCSMRZKBUOFUSRQ-JHCHYBNPSA-N
Purity>98.00%

储存条件

2-8 C, away from moisture, sealed storage

技术属性

Nucleobase
Uracil
Sugar
2'-Deoxyribose
C5 linker
Aminohexanoyl-type long spacer
Amine protection
Trifluoroacetyl (TFA)
Packaging
25 mg; 100 mg; Custom packaging on request

应用背景

  • Long-spacer labeling research: CH64055 combines a 2'-deoxyuridine identity with a C5 TFA-protected "aha" amino-linker for oligonucleotide labeling and linker-spacing studies.
  • Amine-linker labeling studies: the TFA-protected terminal amine represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
  • Base-analog reference: CH64055 provides the 5-TFA-aha-2'-deoxyuridine identity for nucleoside chemistry research.

相关技术资源

寡核苷酸修饰

用于 ASO、siRNA、guide RNA、适配体以及研究或标记项目的糖、碱基、骨架、末端和偶联修饰。

寡核苷酸合成

支持修饰单体、固相载体、硫化试剂、帽类似物和相关寡核苷酸合成输入物。

公开来源

常见问题

How is the 'aha' linker different from the 'ap' linker?

The 'aha' amino-linker is longer than the propynyl 'ap' linker, giving a larger spacer between the base and the terminal amine. The shorter 5-TFA-ap-2'-deoxyuridine is cataloged separately.

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