5-TFA-aa-2'-deoxycytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C14H17F3N4O5
- 分子量
- 378.30
- 纯度
- >=98%
5-TFA-aa-2'-deoxycytidine is 2'-deoxycytidine carrying an aminoallyl amino-linker at the C5 position of cytosine, with the linker's terminal amine protected as a trifluoroacetamide (TFA). CH64059 is identified by CAS 96102-27-1, molecular formula C14H17F3N4O5, molecular weight 378.30, PubChem CID 86280299, and InChIKey WYMZPLFAGMLVFK-HFVMFMDWSA-N.
The aminoallyl arm provides a protected amine-linker motif on a 2'-deoxy nucleoside. The cited labeling literature discusses amine-linker nucleosides in covalent fluorophore attachment and indirect labeling research for nucleic acids.
同义词
5-(trifluoroacetamidoallyl)-2'-deoxycytidine; 5-TFA-aa-dC
身份与规格
| Catalog No. | CH64059 |
| CAS No. | 96102-27-1 |
| Molecular Formula | C14H17F3N4O5 |
| Molecular Weight | 378.30 |
| PubChem CID | 86280299 |
| InChIKey | WYMZPLFAGMLVFK-HFVMFMDWSA-N |
| Purity | >=98% |
储存条件
2-8 C
技术属性
- Nucleobase
- Cytosine
- Sugar
- 2'-Deoxyribose
- C5 linker
- Aminoallyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 1 g; 2 g; 5 g; 25 uL sample solution; Custom packaging on request
- Solution concentration
- 10 mM supplied sample solution
应用背景
- Aminoallyl labeling research: CH64059 combines a 2'-deoxycytidine identity with a C5 TFA-protected aminoallyl linker for indirect DNA and oligonucleotide labeling studies.
- Amine-linker labeling studies: the TFA-protected aminoallyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64059 provides the 5-TFA-aa-2'-deoxycytidine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 86280299
PubChem · CID 86280299
常见问题
What does 'aa' (aminoallyl) mean here?
'aa' is the aminoallyl linker, a 3-aminoprop-1-enyl arm at C5. Its terminal amine is protected as a trifluoroacetamide (TFA).
How is it different from 5-TFA-ap-2'-deoxycytidine?
Both are C5 amino-linker deoxycytidines, but 'aa' is an aminoallyl arm while 'ap' is an aminopropynyl arm. Both are cataloged separately.
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