N2-Isobutyryl-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C14H19N5O5
- 分子量
- 337.33
- 纯度
- >98.0% (HPLC)
N2-Isobutyryl-2'-deoxyguanosine (dGiBu) is 2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64074 is identified by CAS 68892-42-2, molecular formula C14H19N5O5, molecular weight 337.33, PubChem CID 135407017, and InChIKey SIDXEQFMTMICKG-DJLDLDEBSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64074 provides the N2-isobutyryl-protected 2'-deoxyguanosine identity for DNA building-block and nucleoside chemistry research.
同义词
N2-Isobutyryl-2'-deoxyguanosine; N2-ibu-dG; dGiBu
身份与规格
| Catalog No. | CH64074 |
| CAS No. | 68892-42-2 |
| Molecular Formula | C14H19N5O5 |
| Molecular Weight | 337.33 |
| PubChem CID | 135407017 |
| InChIKey | SIDXEQFMTMICKG-DJLDLDEBSA-N |
| Purity | >98.0% (HPLC) |
储存条件
-20 C
技术属性
- Nucleobase
- Guanine
- Sugar
- 2'-Deoxyribose
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 100 mg; 1 g; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
应用背景
- Base-protected DNA building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanine (dG) monomer precursor context: CH64074 is the base-protected 2'-deoxyguanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64074 provides the N2-isobutyryl-2'-deoxyguanosine (dGiBu) identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 135407017
PubChem · CID 135407017
常见问题
Why is the N2-amine of this deoxyguanosine protected with isobutyryl?
In oligonucleotide synthesis the reactive exocyclic amine of guanine is masked with a protecting group such as isobutyryl to prevent side reactions; the isobutyryl group is later removed during deprotection.
How does it differ from 2'-deoxyguanosine?
It carries an isobutyryl group on the guanine N2-amine, whereas 2'-deoxyguanosine is unprotected. 2'-deoxyguanosine is cataloged separately.
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