Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Isobutyryl-2'-deoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64077CAS号110522-75-3纯度>=99%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C13H19N3O5
分子量: 297.31
纯度: >=99%

N4-Isobutyryl-2'-deoxycytidine (dCiBu) is 2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an isobutyryl group. CH64077 is identified by CAS 110522-75-3, molecular formula C13H19N3O5, molecular weight 297.31, PubChem CID 688503, and InChIKey PDTIVAGPIHEWDX-IQJOONFLSA-N.

The cited oligonucleotide-synthesis literature discusses isobutyryl as a labile cytosine base-protecting group and describes removal of base-protecting groups during deprotection. CH64077 provides the N4-isobutyryl-protected 2'-deoxycytidine identity for DNA building-block and nucleoside chemistry research.

同义词

N4-Isobutyryl-2'-deoxycytidine; N4-ibu-dC; dCiBu

身份与规格

Catalog No.	CH64077
CAS No.	110522-75-3
Molecular Formula	C13H19N3O5
Molecular Weight	297.31
PubChem CID	688503
InChIKey	PDTIVAGPIHEWDX-IQJOONFLSA-N
Purity	>=99%

储存条件

0-8 C

技术属性

Nucleobase: Cytosine
Sugar: 2'-Deoxyribose
Base protection: N4-Isobutyryl
Synthesis role: Base-protected DNA nucleoside intermediate
Packaging: 1 g; 5 g; 10 g; 25 g; Custom packaging on request
Physical form: white powder

应用背景

Base-protected DNA building block: the N4-isobutyryl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
Cytosine (dC) monomer precursor context: CH64077 is the isobutyryl-protected 2'-deoxycytidine identity relevant to cytosine building-block preparation.
Nucleoside chemistry reference: CH64077 provides the N4-isobutyryl-2'-deoxycytidine (dCiBu) identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 688503
PubChem · CID 688503

常见问题

Why is the N4-amine of this deoxycytidine protected with isobutyryl?

In oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a labile protecting group such as isobutyryl (a fast-deprotection cytosine protection); the group is later removed during deprotection.

How does it differ from N4-benzoyl- or N4-acetyl-2'-deoxycytidine?

All three protect the cytosine N4-amine, but with different acyl groups (isobutyryl, benzoyl, or acetyl). The benzoyl and acetyl forms are cataloged separately.