Oligonucleotide Synthesis, RNA Raw Materials & Modification

N2-(Dimethylaminomethylene)-2'-deoxyguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64078CAS号17331-13-4纯度>=98.0% (HPLC)

暂无产品图片

产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C13H18N6O4
分子量: 322.32
纯度: >=98.0% (HPLC)

N2-(Dimethylaminomethylene)-2'-deoxyguanosine (dmf-dG) is 2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with a dimethylformamidine (dmf) group. CH64078 is identified by CAS 17331-13-4, molecular formula C13H18N6O4, molecular weight 322.32, PubChem CID 135882612, and InChIKey ZXECVVVXPHBGGX-DJLDLDEBSA-N.

The cited oligonucleotide-synthesis literature discusses dimethylformamidine as a labile guanine base-protecting group and describes removal of base-protecting groups during deprotection. CH64078 provides the N2-dmf-protected 2'-deoxyguanosine identity for DNA building-block and nucleoside chemistry research.

同义词

N2-(Dimethylaminomethylene)-2'-deoxyguanosine; N2-dmf-dG; dG(dmf)

身份与规格

Catalog No.	CH64078
CAS No.	17331-13-4
Molecular Formula	C13H18N6O4
Molecular Weight	322.32
PubChem CID	135882612
InChIKey	ZXECVVVXPHBGGX-DJLDLDEBSA-N
Purity	>=98.0% (HPLC)

储存条件

+2 to +8 C

技术属性

Nucleobase: Guanine
Sugar: 2'-Deoxyribose
Base protection: N2-Dimethylaminomethylene (dmf)
Synthesis role: Base-protected DNA nucleoside intermediate
Packaging: 1 g; 5 g; 10 g; 20 g; 25 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 500 mg; supplied solution: 1 mL; Custom packaging on request
Solution concentration: 10 mM x 1 mL in DMSO supplied solution; 10 mM x 1 mL in DMSO solid-plus-solvent kit
Water content: <=2% KF
Physical form: white to off-white powder
Stability: User-prepared stock solution: 6 months at -80 C; 1 month at -20 C

应用背景

Base-protected DNA building block: the N2-dimethylformamidine group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
Guanine (dG) monomer precursor context: CH64078 is the dmf-protected 2'-deoxyguanosine identity relevant to guanine building-block preparation.
Nucleoside chemistry reference: CH64078 provides the N2-dmf-2'-deoxyguanosine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 135882612
PubChem · CID 135882612

常见问题

How does it differ from N2-isobutyryl-2'-deoxyguanosine?

Both protect the guanine N2-amine, but this one uses a dimethylformamidine (dmf) group rather than isobutyryl. N2-isobutyryl-2'-deoxyguanosine is cataloged separately.