Oligonucleotide Synthesis, RNA Raw Materials & Modification

N6-Benzoyladenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64081CAS号4546-55-8纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C17H17N5O5
分子量: 371.35
纯度: >=98%

N6-Benzoyladenosine (rABz) is adenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64081 is identified by CAS 4546-55-8, molecular formula C17H17N5O5, molecular weight 371.35, PubChem CID 11728391, and InChIKey NZDWTKFDAUOODA-CNEMSGBDSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64081 provides the N6-benzoyl-protected adenosine identity for RNA building-block and nucleoside chemistry research.

同义词

N6-Benzoyladenosine; N6-Bz-rA; rABz

身份与规格

Catalog No.	CH64081
CAS No.	4546-55-8
Molecular Formula	C17H17N5O5
Molecular Weight	371.35
PubChem CID	11728391
InChIKey	NZDWTKFDAUOODA-CNEMSGBDSA-N
Purity	>=98%

储存条件

Room temperature; recommended cool and dark below 15 C

技术属性

Nucleobase: Adenine
Sugar: D-Ribose
Base protection: N6-Benzoyl
Synthesis role: Base-protected RNA nucleoside intermediate
Packaging: 1 g; 5 g; Custom packaging on request
Water content: <=8.0%
Physical form: solid; white to almost white powder to crystal

应用背景

Base-protected RNA building block: the N6-benzoyl group masks the adenine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
Adenosine (rA) monomer precursor context: CH64081 is the base-protected adenosine identity relevant to adenine building-block preparation.
Nucleoside chemistry reference: CH64081 provides the N6-benzoyladenosine (rABz) identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 11728391
PubChem · CID 11728391

常见问题

Why is the N6-amine of this adenosine benzoylated?

In RNA oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.

How does it differ from N6-benzoyl-2'-deoxyadenosine?

Both carry an N6-benzoyl-protected adenine, but this one is the ribonucleoside (2'-OH), while N6-benzoyl-2'-deoxyadenosine is the 2'-deoxy form. Both are cataloged separately.