Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Benzoylcytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64082CAS号13089-48-0纯度99%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C16H17N3O6
分子量: 347.32
纯度: 99%

N4-Benzoylcytidine (rCBz) is cytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64082 is identified by CAS 13089-48-0, molecular formula C16H17N3O6, molecular weight 347.32, PubChem CID 10066259, and InChIKey BNXBRFDWSPXODM-BPGGGUHBSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64082 provides the N4-benzoyl-protected cytidine identity for RNA building-block and nucleoside chemistry research.

同义词

N4-Benzoylcytidine; N4-Bz-rC; rCBz

身份与规格

Catalog No.	CH64082
CAS No.	13089-48-0
Molecular Formula	C16H17N3O6
Molecular Weight	347.32
PubChem CID	10066259
InChIKey	BNXBRFDWSPXODM-BPGGGUHBSA-N
Purity	99%

储存条件

Room temperature; recommended cool and dark below 15 C; store under inert gas; hygroscopic

技术属性

Nucleobase: Cytosine
Sugar: D-Ribose
Base protection: N4-Benzoyl
Synthesis role: Base-protected RNA nucleoside intermediate
Packaging: 1 g; 5 g; Custom packaging on request
Physical form: solid; white to almost white powder to crystal

应用背景

Base-protected RNA building block: the N4-benzoyl group masks the cytosine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
Cytidine (rC) monomer precursor context: CH64082 is the base-protected cytidine identity relevant to cytosine building-block preparation.
Nucleoside chemistry reference: CH64082 provides the N4-benzoylcytidine (rCBz) identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 10066259
PubChem · CID 10066259

常见问题

Why is the N4-amine of this cytidine benzoylated?

In RNA oligonucleotide synthesis the reactive exocyclic amine of cytosine is masked with a protecting group such as benzoyl to prevent side reactions; the benzoyl group is later removed during deprotection.

How does it differ from N4-benzoyl-2'-deoxycytidine?

Both carry an N4-benzoyl-protected cytosine, but this one is the ribonucleoside (2'-OH), while N4-benzoyl-2'-deoxycytidine is the 2'-deoxy form. Both are cataloged separately.