N2-Isobutyrylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C14H19N5O6
- 分子量
- 353.33
- 纯度
- 95%
N2-Isobutyrylguanosine (rGiBu) is guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64083 is identified by CAS 64350-24-9, molecular formula C14H19N5O6, molecular weight 353.33, PubChem CID 135722152, and InChIKey OXTYJSXVUGJSGM-HTVVRFAVSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64083 provides the N2-isobutyryl-protected guanosine identity for RNA building-block and nucleoside chemistry research.
同义词
N2-Isobutyrylguanosine; N2-ibu-rG; rGiBu
身份与规格
| Catalog No. | CH64083 |
| CAS No. | 64350-24-9 |
| Molecular Formula | C14H19N5O6 |
| Molecular Weight | 353.33 |
| PubChem CID | 135722152 |
| InChIKey | OXTYJSXVUGJSGM-HTVVRFAVSA-N |
| Purity | 95% |
储存条件
Refrigerator
技术属性
- Nucleobase
- Guanine
- Sugar
- D-Ribose
- Base protection
- N2-Isobutyryl
- Synthesis role
- Base-protected RNA nucleoside intermediate
- Packaging
- 1 g; 5 g; 10 g; Custom packaging on request
- Physical form
- crystal-powder; white to almost white
应用背景
- Base-protected RNA building block: the N2-isobutyryl group masks the guanine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
- Guanosine (rG) monomer precursor context: CH64083 is the base-protected guanosine identity relevant to guanine building-block preparation.
- Nucleoside chemistry reference: CH64083 provides the N2-isobutyrylguanosine (rGiBu) identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 135722152
PubChem · CID 135722152
常见问题
Why is the N2-amine of this guanosine protected with isobutyryl?
In RNA oligonucleotide synthesis the reactive exocyclic amine of guanine is masked with a protecting group such as isobutyryl to prevent side reactions; the isobutyryl group is later removed during deprotection.
How does it differ from N2-isobutyryl-2'-deoxyguanosine?
Both carry an N2-isobutyryl-protected guanine, but this one is the ribonucleoside (2'-OH), while N2-isobutyryl-2'-deoxyguanosine is the 2'-deoxy form. Both are cataloged separately.
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