Oligonucleotide Synthesis, RNA Raw Materials & Modification

N6-Methyladenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64084CAS号1867-73-8纯度99.75%

暂无产品图片

产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C11H15N5O4
分子量: 281.27
纯度: 99.75%

N6-Methyladenosine (m6A) is adenosine methylated at the adenine N6 position, corresponding to the nucleoside form of the RNA modification m6A. CH64084 is identified by CAS 1867-73-8, molecular formula C11H15N5O4, molecular weight 281.27, PubChem CID 102175, and InChIKey VQAYFKKCNSOZKM-IOSLPCCCSA-N.

The cited literature discusses m6A as the most abundant internal modification in mRNA and as an epitranscriptomic mark. Unlike acyl-protected building blocks, the N6-methyl group is a permanent base modification, not a removable protecting group.

同义词

N6-Methyladenosine; m6A; N6-methyl-rA

身份与规格

Catalog No.	CH64084
CAS No.	1867-73-8
Molecular Formula	C11H15N5O4
Molecular Weight	281.27
PubChem CID	102175
InChIKey	VQAYFKKCNSOZKM-IOSLPCCCSA-N
Purity	99.75%

储存条件

-20 C

技术属性

Nucleobase: Adenine
Sugar: D-Ribose
Base modification: N6-Methyl (m6A)
Research role: RNA epitranscriptomic-mark nucleoside reference
Packaging: 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 25 mg; supplied solution: 1 mL; Custom packaging on request
Solution concentration: Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
Physical form: crystalline solid
Stability: >=4 years

应用背景

m6A epitranscriptomic-mark research: CH64084 is the nucleoside form of m6A, the RNA modification discussed in the cited literature as the most abundant internal mRNA modification.
Base-modified nucleoside reference: CH64084 provides the N6-methyladenosine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 102175
PubChem · CID 102175

常见问题

Is the N6-methyl group a protecting group?

No. Unlike N6-acyl building blocks such as benzoyl- or 4-methoxybenzoyl-protected adenosine, the N6-methyl here is a permanent base modification and is not removed during deprotection.