Oligonucleotide Synthesis, RNA Raw Materials & Modification

N2-Phenoxyacetylguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64085CAS号119824-66-7纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C18H19N5O7
分子量: 417.37
纯度: >=98%

N2-Phenoxyacetylguanosine (rG PAc) is guanosine whose guanine exocyclic N2-amine is protected with a phenoxyacetyl (PAc) group. CH64085 is identified by CAS 119824-66-7, molecular formula C18H19N5O7, molecular weight 417.37, PubChem CID 135921574, and InChIKey FOOYAXZEBFXEJD-IWCJZZDYSA-N.

The cited oligonucleotide-synthesis literature discusses labile exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64085 provides the N2-phenoxyacetyl-protected guanosine identity for RNA building-block and nucleoside chemistry research.

同义词

N2-Phenoxyacetylguanosine; N2-PAc-rG; rG(PAc)

身份与规格

Catalog No.	CH64085
CAS No.	119824-66-7
Molecular Formula	C18H19N5O7
Molecular Weight	417.37
PubChem CID	135921574
InChIKey	FOOYAXZEBFXEJD-IWCJZZDYSA-N
Purity	>=98%

技术属性

Nucleobase: Guanine
Sugar: D-Ribose
Base protection: N2-Phenoxyacetyl (PAc)
Synthesis role: Base-protected RNA nucleoside intermediate
Packaging: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 25 g; 100 g; Custom packaging on request

应用背景

Base-protected RNA building block: the N2-phenoxyacetyl (PAc) group masks the guanine exocyclic amine in RNA oligonucleotide-synthesis chemistry and is removed during deprotection.
Guanosine (rG) monomer precursor context: CH64085 is the PAc-protected guanosine identity relevant to guanine building-block preparation.
Nucleoside chemistry reference: CH64085 provides the N2-phenoxyacetylguanosine (rG PAc) identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 135921574
PubChem · CID 135921574

常见问题

What is the 'PAc' group on this guanosine?

PAc is phenoxyacetyl. In CH64085, the group is on the guanine exocyclic N2-amine and is part of the base-protected guanosine identity.

How does it differ from N2-isobutyrylguanosine?

Both protect the guanine N2-amine, but this one uses a phenoxyacetyl (PAc) group rather than isobutyryl. N2-isobutyrylguanosine is cataloged separately.