N6-Benzoyl-2'-O-methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C18H19N5O5
- 分子量
- 385.37
- 纯度
- >=98.0% (HPLC)
N6-Benzoyl-2'-O-methyladenosine is 2'-O-methyladenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64086 is identified by CAS 85079-00-1, molecular formula C18H19N5O5, molecular weight 385.37, PubChem CID 13852840, and InChIKey PHFHSPQCDRKMQJ-XWXWGSFUSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
同义词
N6-Benzoyl-2'-O-methyladenosine; N6-Bz-2'-OMe-rA; 2'-OMe-rA(Bz)
身份与规格
| Catalog No. | CH64086 |
| CAS No. | 85079-00-1 |
| Molecular Formula | C18H19N5O5 |
| Molecular Weight | 385.37 |
| PubChem CID | 13852840 |
| InChIKey | PHFHSPQCDRKMQJ-XWXWGSFUSA-N |
| Purity | >=98.0% (HPLC) |
储存条件
2-8 C; keep dark and dry
技术属性
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 1 g; 5 g; Custom packaging on request
- Water content
- <=6.0%
- Physical form
- white powder
应用背景
- Base-protected 2'-OMe building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64086 provides the N6-benzoyl-2'-O-methyladenosine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 13852840
PubChem · CID 13852840
常见问题
How does it differ from N6-benzoyladenosine?
Both carry an N6-benzoyl-protected adenine, but this one also has a 2'-O-methyl sugar modification, whereas N6-benzoyladenosine has a free 2'-OH. N6-benzoyladenosine is cataloged separately.
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