Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Benzoyl-2'-O-methylcytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64087CAS号52571-45-6纯度99.21%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C17H19N3O6
分子量: 361.35
纯度: 99.21%

N4-Benzoyl-2'-O-methylcytidine is 2'-O-methylcytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64087 is identified by CAS 52571-45-6, molecular formula C17H19N3O6, molecular weight 361.35, PubChem CID 13852838, and InChIKey LIZIIHWLABYQKD-XKVFNRALSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

同义词

N4-Benzoyl-2'-O-methylcytidine; N4-Bz-2'-OMe-rC; 2'-OMe-rC(Bz)

身份与规格

Catalog No.	CH64087
CAS No.	52571-45-6
Molecular Formula	C17H19N3O6
Molecular Weight	361.35
PubChem CID	13852838
InChIKey	LIZIIHWLABYQKD-XKVFNRALSA-N
Purity	99.21%

储存条件

2-8 C

技术属性

Nucleobase: Cytosine
Sugar modification: 2'-O-Methyl
Base protection: N4-Benzoyl
Synthesis role: Base-protected 2'-O-methyl nucleoside intermediate
Packaging: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; solid-plus-solvent kit: 1 mL reconstitution volume; Solid: 100 mg; supplied solution: 1 mL; Custom packaging on request
Solution concentration: Supplied solution: 10 mM x 1 mL in DMSO; solid-plus-solvent kit: 10 mM x 1 mL in DMSO ready for reconstitution
Water content: <=2.0%
Physical form: white to off-white powder

应用背景

Base-protected 2'-OMe building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
Nucleoside chemistry reference: CH64087 provides the N4-benzoyl-2'-O-methylcytidine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 13852838
PubChem · CID 13852838

常见问题

How does it differ from N4-benzoylcytidine?

Both carry an N4-benzoyl-protected cytosine, but this one also has a 2'-O-methyl sugar modification, whereas N4-benzoylcytidine has a free 2'-OH. N4-benzoylcytidine is cataloged separately.