N2-(Dimethylaminomethylene)-2'-O-methylguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C14H20N6O5
- 分子量
- 352.35
- 纯度
- >=97.0% (HPLC)
N2-(Dimethylaminomethylene)-2'-O-methylguanosine is 2'-O-methylguanosine whose guanine exocyclic N2-amine is protected with a dimethylformamidine (dmf) group. CH64089 is identified by CAS 183737-04-4, molecular formula C14H20N6O5, molecular weight 352.35, PubChem CID 136119103, and InChIKey KDQQTCFKBCWYFL-QYVSTXNMSA-N.
The cited oligonucleotide-synthesis literature discusses dimethylformamidine as a labile guanine base-protecting group and its removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.
同义词
N2-(Dimethylaminomethylene)-2'-O-methylguanosine; N2-dmf-2'-OMe-rG; 2'-OMe-rG(dmf)
身份与规格
| Catalog No. | CH64089 |
| CAS No. | 183737-04-4 |
| Molecular Formula | C14H20N6O5 |
| Molecular Weight | 352.35 |
| PubChem CID | 136119103 |
| InChIKey | KDQQTCFKBCWYFL-QYVSTXNMSA-N |
| Purity | >=97.0% (HPLC) |
储存条件
2-8 C
技术属性
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-Methyl
- Base protection
- N2-Dimethylaminomethylene (dmf)
- Synthesis role
- Base-protected 2'-O-methyl nucleoside intermediate
- Packaging
- 10 mg; 50 mg; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white off-white to faint yellow powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
应用背景
- Base-protected 2'-OMe building block: the N2-dmf group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
- Nucleoside chemistry reference: CH64089 provides the N2-dmf-2'-O-methylguanosine identity for nucleoside chemistry research.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 136119103
PubChem · CID 136119103
常见问题
How does it differ from N2-dmf-2'-deoxyguanosine?
Both carry an N2-dmf-protected guanine, but this one is a ribonucleoside with a 2'-O-methyl sugar modification, while N2-dmf-2'-deoxyguanosine is the 2'-deoxy form. That one is cataloged separately.
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