Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Acetyl-2'-O-methylcytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64090CAS号113886-71-8纯度99.62%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C12H17N3O6
分子量: 299.28
纯度: 99.62%

N4-Acetyl-2'-O-methylcytidine is 2'-O-methylcytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64090 is identified by CAS 113886-71-8, molecular formula C12H17N3O6, molecular weight 299.28, PubChem CID 10902616, and InChIKey CYDFBLGNJUNSCC-QCNRFFRDSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

同义词

N4-Acetyl-2'-O-methylcytidine; N4-Ac-2'-OMe-rC; 2'-OMe-rC(Ac)

身份与规格

Catalog No.	CH64090
CAS No.	113886-71-8
Molecular Formula	C12H17N3O6
Molecular Weight	299.28
PubChem CID	10902616
InChIKey	CYDFBLGNJUNSCC-QCNRFFRDSA-N
Purity	99.62%

储存条件

+4 C

技术属性

Nucleobase: Cytosine
Sugar modification: 2'-O-Methyl
Base protection: N4-Acetyl
Synthesis role: Base-protected 2'-O-methyl nucleoside intermediate
Packaging: 10 mg; 25 mg; 100 mg; 500 mg; 1 mL x 10 mM (in DMSO); Custom packaging on request
Solution concentration: 10 mM in DMSO
Water content: <=2.0%
Physical form: white to off-white powder
Stability: >=4 years

应用背景

Base-protected 2'-OMe building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
Nucleoside chemistry reference: CH64090 provides the N4-acetyl-2'-O-methylcytidine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 10902616
PubChem · CID 10902616

常见问题

How does it differ from N4-benzoyl-2'-O-methylcytidine?

Both are 2'-O-methylcytidine with a protected cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. The benzoyl form is cataloged separately.