Oligonucleotide Synthesis, RNA Raw Materials & Modification

N6-Benzoyl-2'-fluoro-2'-deoxyadenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64091CAS号136834-20-3纯度99.92%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C17H16FN5O4
分子量: 373.34
纯度: 99.92%

N6-Benzoyl-2'-fluoro-2'-deoxyadenosine is 2'-fluoro-2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64091 is identified by CAS 136834-20-3, molecular formula C17H16FN5O4, molecular weight 373.34, PubChem CID 11760510, and InChIKey HLJZTLWDAQVZBU-YAMOITTJSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.

同义词

N6-Benzoyl-2'-fluoro-2'-deoxyadenosine; N6-Bz-2'-F-dA; 2'-F-rA(Bz)

身份与规格

Catalog No.	CH64091
CAS No.	136834-20-3
Molecular Formula	C17H16FN5O4
Molecular Weight	373.34
PubChem CID	11760510
InChIKey	HLJZTLWDAQVZBU-YAMOITTJSA-N
Purity	99.92%

储存条件

2-8 C; keep dark and dry

技术属性

Nucleobase: Adenine
Sugar modification: 2'-Fluoro-2'-deoxy
Base protection: N6-Benzoyl
Synthesis role: Base-protected 2'-fluoro nucleoside intermediate
Packaging: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; solution 1 mL x 10 mM in DMSO; Custom packaging on request
Solution concentration: 10 mM in DMSO
Water content: <=2.0%
Physical form: white powder
Stability: Powder: 3 years at -20 C or 2 years at 4 C; in solvent: 6 months at -80 C or 1 month at -20 C

应用背景

Base-protected 2'-F building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-Fluoro sugar modification context: cited 2'-fluoro oligonucleotide literature discusses RNA affinity and nuclease resistance.
Nucleoside chemistry reference: CH64091 provides the N6-benzoyl-2'-fluoro-2'-deoxyadenosine identity for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 11760510
PubChem · CID 11760510

常见问题

How does it differ from N6-benzoyl-2'-O-methyladenosine?

Both are N6-benzoyl base-protected adenosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.