Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Benzoyl-2'-fluoro-2'-deoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64092CAS号146954-76-9纯度>=98.0% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C16H16FN3O5
分子量: 349.31
纯度: >=98.0% (HPLC)

N4-Benzoyl-2'-fluoro-2'-deoxycytidine is 2'-fluoro-2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64092 is identified by CAS 146954-76-9, molecular formula C16H16FN3O5, molecular weight 349.31, PubChem CID 54266478, and InChIKey RHCOKFXBQWNMHE-BPGGGUHBSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.

同义词

N4-Benzoyl-2'-fluoro-2'-deoxycytidine; N4-Bz-2'-F-dC; 2'-F-rC(Bz)

身份与规格

Catalog No.	CH64092
CAS No.	146954-76-9
Molecular Formula	C16H16FN3O5
Molecular Weight	349.31
PubChem CID	54266478
InChIKey	RHCOKFXBQWNMHE-BPGGGUHBSA-N
Purity	>=98.0% (HPLC)

储存条件

2-8 C; keep dark and dry

技术属性

Nucleobase: Cytosine
Sugar modification: 2'-Fluoro-2'-deoxy
Base protection: N4-Benzoyl
Synthesis role: Base-protected 2'-fluoro nucleoside intermediate
Packaging: Custom packaging on request
Water content: <=2.0%
Physical form: white powder

应用背景

Base-protected 2'-F building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Nucleoside chemistry identity: a defined N4-benzoyl-2'-fluoro-2'-deoxycytidine compound for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 54266478
PubChem · CID 54266478

常见问题

How does it differ from N4-benzoyl-2'-O-methylcytidine?

Both are N4-benzoyl base-protected cytidines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.