Oligonucleotide Synthesis, RNA Raw Materials & Modification

N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64093CAS号80681-25-0纯度>=98.0% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C14H18FN5O5
分子量: 355.32
纯度: >=98.0% (HPLC)

N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine is 2'-fluoro-2'-deoxyguanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64093 is identified by CAS 80681-25-0, molecular formula C14H18FN5O5, molecular weight 355.32, PubChem CID 135742141, and InChIKey SLHADUUWJSVYGQ-HTFXMJNNSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.

同义词

N2-Isobutyryl-2'-fluoro-2'-deoxyguanosine; N2-ibu-2'-F-dG; 2'-F-rG(iBu)

身份与规格

Catalog No.	CH64093
CAS No.	80681-25-0
Molecular Formula	C14H18FN5O5
Molecular Weight	355.32
PubChem CID	135742141
InChIKey	SLHADUUWJSVYGQ-HTFXMJNNSA-N
Purity	>=98.0% (HPLC)

储存条件

2-8 C; keep dark and dry

技术属性

Nucleobase: Guanine
Sugar modification: 2'-Fluoro-2'-deoxy
Base protection: N2-Isobutyryl
Synthesis role: Base-protected 2'-fluoro nucleoside intermediate
Packaging: Custom packaging on request
Water content: <=2.0%
Physical form: white powder

应用背景

Base-protected 2'-F building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Nucleoside chemistry identity: a defined N2-isobutyryl-2'-fluoro-2'-deoxyguanosine compound for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 135742141
PubChem · CID 135742141

常见问题

How does it differ from N2-isobutyryl-2'-O-methylguanosine?

Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-fluoro sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.