Oligonucleotide Synthesis, RNA Raw Materials & Modification

N4-Acetyl-2'-fluoro-2'-deoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64094CAS号159414-97-8纯度>=99.0% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C11H14FN3O5
分子量: 287.24
纯度: >=99.0% (HPLC)

N4-Acetyl-2'-fluoro-2'-deoxycytidine is 2'-fluoro-2'-deoxycytidine whose cytosine exocyclic N4-amine is protected with an acetyl group. CH64094 is identified by CAS 159414-97-8, molecular formula C11H14FN3O5, molecular weight 287.24, PubChem CID 22094552, and InChIKey NLXVKEFNBVLDLD-PEBGCTIMSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.

同义词

N4-Acetyl-2'-fluoro-2'-deoxycytidine; N4-Ac-2'-F-dC; 2'-F-rC(Ac)

身份与规格

Catalog No.	CH64094
CAS No.	159414-97-8
Molecular Formula	C11H14FN3O5
Molecular Weight	287.24
PubChem CID	22094552
InChIKey	NLXVKEFNBVLDLD-PEBGCTIMSA-N
Purity	>=99.0% (HPLC)

储存条件

2-8 C; keep dark and dry

技术属性

Nucleobase: Cytosine
Sugar modification: 2'-Fluoro-2'-deoxy
Base protection: N4-Acetyl
Synthesis role: Base-protected 2'-fluoro nucleoside intermediate
Packaging: Custom packaging on request
Water content: <=5.0%
Physical form: white powder
Stability: In solvent: 6 months at -80 C or 1 month at -20 C

应用背景

Base-protected 2'-F building block: the N4-acetyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-Fluoro sugar modification context: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
Nucleoside chemistry identity: a defined N4-acetyl-2'-fluoro-2'-deoxycytidine compound for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 22094552
PubChem · CID 22094552

常见问题

How does it differ from N4-benzoyl-2'-fluoro-2'-deoxycytidine?

Both are 2'-fluoro cytidines with a protected cytosine N4-amine, but this one uses an acetyl group rather than benzoyl. The benzoyl form is cataloged separately.