2'-O-MOE-N4-Benzoyl-5-methylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C20H25N3O7
- 分子量
- 419.43
- 纯度
- >=98%
2'-O-MOE-N4-Benzoyl-5-methylcytidine is 2'-O-(2-methoxyethyl)-5-methylcytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group; its base is 5-methylcytosine. CH64097 is identified by CAS 340162-93-8, molecular formula C20H25N3O7, molecular weight 419.43, PubChem CID 20660421, and InChIKey LGGHYGUGIGYDFX-YKTARERQSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
同义词
2'-O-MOE-N4-Benzoyl-5-methylcytidine; 2'-O-(2-methoxyethyl)-N4-benzoyl-5-methylcytidine; MOE-5Me-rC(Bz)
身份与规格
| Catalog No. | CH64097 |
| CAS No. | 340162-93-8 |
| Molecular Formula | C20H25N3O7 |
| Molecular Weight | 419.43 |
| PubChem CID | 20660421 |
| InChIKey | LGGHYGUGIGYDFX-YKTARERQSA-N |
| Purity | >=98% |
储存条件
2-8 C
技术属性
- Nucleobase
- 5-Methylcytosine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected MOE nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
应用背景
- Base-protected 2'-O-MOE building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
- 5-Methylcytosine base: the compound contains a 5-methylcytosine base, described here as a structural identity feature.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 20660421
PubChem · CID 20660421
常见问题
How does it differ from 2'-O-MOE-N4-benzoylcytidine?
Both are N4-benzoyl base-protected 2'-MOE cytidines, but this one has a 5-methylcytosine base (an extra methyl on the base). The non-methylated form is cataloged separately.
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