Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-MOE-N2-Isobutyrylguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH64098CAS号440327-50-4纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C17H25N5O7
分子量: 411.41
纯度: >=98%

2'-O-MOE-N2-Isobutyrylguanosine is 2'-O-(2-methoxyethyl)guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64098 is identified by CAS 440327-50-4, molecular formula C17H25N5O7, molecular weight 411.41, PubChem CID 136162613, and InChIKey IZOOGJIUOCHAAY-UBEDBUPSSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.

同义词

2'-O-MOE-N2-Isobutyrylguanosine; 2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine; MOE-rG(iBu)

身份与规格

Catalog No.	CH64098
CAS No.	440327-50-4
Molecular Formula	C17H25N5O7
Molecular Weight	411.41
PubChem CID	136162613
InChIKey	IZOOGJIUOCHAAY-UBEDBUPSSA-N
Purity	>=98%

储存条件

2-8 C

技术属性

Nucleobase: Guanine
Sugar modification: 2'-O-(2-Methoxyethyl) (MOE)
Base protection: N2-Isobutyryl
Synthesis role: Base-protected MOE nucleoside intermediate
Packaging: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
Water content: <=2.0%
Physical form: white to off-white powder
Stability: Powder: 3 years at -20 C; in solvent: 1 year at -80 C

应用背景

Base-protected 2'-O-MOE building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
Nucleoside chemistry identity: a defined 2'-O-MOE-N2-isobutyrylguanosine compound for nucleoside chemistry research.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 136162613
PubChem · CID 136162613

常见问题

How does it differ from N2-isobutyryl-2'-O-methylguanosine?

Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.