5'-O-DMT-2'-fluoro-2'-deoxyuridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C30H29FN2O7
- 分子量
- 548.6
- 纯度
- >=99%
5'-O-DMT-2'-fluoro-2'-deoxyuridine is 2'-fluoro-2'-deoxyuridine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64125 is identified by CAS 146954-74-7, molecular formula C30H29FN2O7, molecular weight 548.6, PubChem CID 7073186, and InChIKey CSSFZSSZXOCCJB-YULOIDQLSA-N.
It is a 2'-F-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance. Because uracil has no exocyclic amine, no base protecting group is required.
同义词
5'-O-DMT-2'-fluoro-2'-deoxyuridine; 5'-O-DMT-2'-F-rU; DMT-2'-F-rU
身份与规格
| Catalog No. | CH64125 |
| CAS No. | 146954-74-7 |
| Molecular Formula | C30H29FN2O7 |
| Molecular Weight | 548.6 |
| PubChem CID | 7073186 |
| InChIKey | CSSFZSSZXOCCJB-YULOIDQLSA-N |
| Purity | >=99% |
储存条件
2-8 C, tightly closed, protected from light and humidity
技术属性
- Nucleobase
- Uracil
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- Unprotected
- Grade
- N (Normal)
- Packaging
- 1 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 200 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white, off-white to faint yellow powder
应用背景
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-Fluoro sugar modification: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- No base protection needed: uracil has no exocyclic amine, so this building block requires no base protecting group.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 7073186
PubChem · CID 7073186
常见问题
How does it differ from 5'-O-DMT-2'-O-methyluridine?
Both are 5'-O-DMT-protected uridines, but this one has a 2'-fluoro modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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