CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-OMe-Guanosine (iBu) CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH65019CAS号150780-67-9纯度100% (NMR)
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产品概述

快速信息

产品系列
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C45H56N7O9P
分子量
869.9
纯度
100% (NMR)

2'-OMe-Guanosine (iBu) CE Phosphoramidite is the 2'-O-methyl guanosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65019 is identified by CAS 150780-67-9, molecular formula C45H56N7O9P, molecular weight 869.9, PubChem CID 135587728, and InChIKey IRRDHRZUOZNWDJ-MLLDKZSOSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

同义词

DMT-2'-OMe-rG(iBu) phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite

身份与规格

Catalog No.CH65019
CAS No.150780-67-9
Molecular FormulaC45H56N7O9P
Molecular Weight869.9
PubChem CID135587728
InChIKeyIRRDHRZUOZNWDJ-MLLDKZSOSA-N
Purity100% (NMR)

储存条件

-20 C

技术属性

Monomer class
2'-O-methyl RNA CE phosphoramidite
Nucleobase
Guanine
Sugar modification
2'-O-Methyl
Base protection
N2-Isobutyryl
Grade
N (Normal)
Packaging
250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g; 200 g; 500 g; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder
Stability
Manufactured 2019-08-16; retest 2023-02-16; expired 2023-08-15

应用背景

  • 2'-OMe RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 2'-OMe sugar modification: cited 2'-O-methyl oligonucleotide literature discusses nuclease resistance and RNA affinity.
  • 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.

相关技术资源

寡核苷酸修饰

用于 ASO、siRNA、guide RNA、适配体以及研究或标记项目的糖、碱基、骨架、末端和偶联修饰。

寡核苷酸合成

支持修饰单体、固相载体、硫化试剂、帽类似物和相关寡核苷酸合成输入物。

公开来源

常见问题

How does it relate to 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine?

It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.

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