Morpholino A Subunit (PMO)
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C38H37ClN7O4P
- 分子量
- 722.2
- 纯度
- >=99%
Morpholino A Subunit is the adenine building block for phosphorodiamidate morpholino oligomer (PMO) synthesis. It is a morpholine ring bearing a base-protected (benzoyl) adenine, a trityl-protected morpholine nitrogen, and an activated phosphorodiamidochloridate coupling group. CH65041 is identified by CAS 956139-18-7, molecular formula C38H37ClN7O4P, molecular weight 722.2, PubChem CID 16662131, and InChIKey HRNHOEBQNIMEGD-RJFDGRJRSA-N.
PMOs are nonionic DNA analogs in which a morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate. This activated subunit provides the adenine morpholino subunit identity for PMO assembly.
同义词
PMO adenine subunit; morpholino adenosine chlorophosphoramidate subunit
身份与规格
| Catalog No. | CH65041 |
| CAS No. | 956139-18-7 |
| Molecular Formula | C38H37ClN7O4P |
| Molecular Weight | 722.2 |
| PubChem CID | 16662131 |
| InChIKey | HRNHOEBQNIMEGD-RJFDGRJRSA-N |
| Purity | >=99% |
储存条件
-20 C
技术属性
- Monomer class
- PMO morpholino subunit
- Nucleobase
- Adenine
- Backbone scaffold
- Morpholine
- Activated group
- Phosphorodiamidochloridate
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
应用背景
- PMO adenine building block: provides the adenine morpholino subunit identity for phosphorodiamidate morpholino oligomer (PMO) synthesis.
- Morpholino backbone: the morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate, giving a nonionic oligomer.
- Protected, activated subunit: the adenine base is benzoyl-protected, the morpholine nitrogen is trityl-protected, and the phosphorodiamidochloridate is the reactive coupling group.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 16662131
PubChem · CID 16662131
常见问题
What is a morpholino (PMO) subunit?
It is a building block for phosphorodiamidate morpholino oligomers (PMOs), nonionic DNA analogs in which a morpholine ring replaces the ribose and phosphorodiamidate linkages replace the phosphates. This product provides the adenine morpholino subunit identity.
How is it protected and activated?
The adenine base is benzoyl-protected, the morpholine nitrogen is trityl-protected, and the reactive phosphorodiamidochloridate group is the coupling handle for PMO chain extension.
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