Morpholino T Subunit (PMO)
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C31H34ClN4O5P
- 分子量
- 609.0
- 纯度
- >=98.0% (HPLC)
Morpholino T Subunit is the thymine building block for phosphorodiamidate morpholino oligomer (PMO) synthesis. It is a morpholine ring bearing a thymine base, a trityl-protected morpholine nitrogen, and an activated phosphorodiamidochloridate coupling group. CH65044 is identified by CAS 956139-30-3, molecular formula C31H34ClN4O5P, molecular weight 609.0, PubChem CID 16662134, and InChIKey DIRYYUMNQFXZQD-ZFXAPSKHSA-N.
PMOs are nonionic DNA analogs in which a morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate. This activated subunit provides the thymine morpholino subunit identity for PMO assembly. Because thymine has no exocyclic amine, no base protecting group is required.
同义词
PMO thymine subunit; morpholino thymidine chlorophosphoramidate subunit
身份与规格
| Catalog No. | CH65044 |
| CAS No. | 956139-30-3 |
| Molecular Formula | C31H34ClN4O5P |
| Molecular Weight | 609.0 |
| PubChem CID | 16662134 |
| InChIKey | DIRYYUMNQFXZQD-ZFXAPSKHSA-N |
| Purity | >=98.0% (HPLC) |
储存条件
-20 C
技术属性
- Monomer class
- PMO morpholino subunit
- Nucleobase
- Thymine
- Backbone scaffold
- Morpholine
- Activated group
- Phosphorodiamidochloridate
- Grade
- N (Normal)
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
应用背景
- PMO thymine building block: provides the thymine morpholino subunit identity for phosphorodiamidate morpholino oligomer (PMO) synthesis.
- Morpholino backbone: the morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate, giving a nonionic oligomer.
- Trityl-protected, activated subunit: the morpholine nitrogen is trityl-protected and the phosphorodiamidochloridate is the reactive coupling group; thymine needs no base protection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 16662134
PubChem · CID 16662134
常见问题
What is a morpholino (PMO) subunit?
It is a building block for phosphorodiamidate morpholino oligomers (PMOs), nonionic DNA analogs in which a morpholine ring replaces the ribose and phosphorodiamidate linkages replace the phosphates. This product provides the thymine morpholino subunit identity.
Why does the thymine subunit have no base protecting group?
Thymine has no reactive exocyclic amine, so it needs no base protection. The subunit carries a trityl-protected morpholine nitrogen and the reactive phosphorodiamidochloridate coupling group.
相似产品
需要协助选择物料？
CHEMOS 可协助评估产品匹配、目标结构、路线问题、分析要求和项目供应需求。