(S)-GNA-A(Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C45H50N7O6P
- 分子量
- 815.9
- 纯度
- >=98.0% (HPLC)
(S)-GNA-A(Bz) CE Phosphoramidite is the glycol nucleic acid (GNA) adenine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing an N6-benzoyl adenine, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65055 is identified by CAS 851050-24-3, molecular formula C45H50N7O6P, molecular weight 815.9, PubChem CID 102511305, and InChIKey RHPZFMWWZNRHHT-MXHUVDEASA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain, the acid-labile DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
同义词
(S)-GNA-A(Bz) phosphoramidite; DMT-(S)-glycol-N6-benzoyladenine CE phosphoramidite
身份与规格
| Catalog No. | CH65055 |
| CAS No. | 851050-24-3 |
| Molecular Formula | C45H50N7O6P |
| Molecular Weight | 815.9 |
| PubChem CID | 102511305 |
| InChIKey | RHPZFMWWZNRHHT-MXHUVDEASA-N |
| Purity | >=98.0% (HPLC) |
储存条件
-20 C
技术属性
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Adenine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- N6-benzoyl
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
应用背景
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- DMT + N6-benzoyl protection: the acid-labile DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 102511305
PubChem · CID 102511305
常见问题
What residue identity does this GNA amidite provide?
It provides the (S)-GNA adenine residue identity through its phosphoramidite coupling group, with DMT removed each cycle and N6-benzoyl removed at final deprotection.
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