(S)-GNA-T CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C38H47N4O7P
- 分子量
- 702.8
- 纯度
- >=99% (HPLC)
(S)-GNA-T CE Phosphoramidite is the glycol nucleic acid (GNA) thymine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing a thymine base, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65058 is identified by CAS 168332-13-6, molecular formula C38H47N4O7P, molecular weight 702.8, PubChem CID 102511306, and InChIKey RIVAXSKTYGDAOA-NMIPJSAASA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain and the acid-labile DMT is removed each cycle. Because thymine has no exocyclic amine, no base protecting group is required.
同义词
(S)-GNA-T phosphoramidite; DMT-(S)-glycol-thymine CE phosphoramidite
身份与规格
| Catalog No. | CH65058 |
| CAS No. | 168332-13-6 |
| Molecular Formula | C38H47N4O7P |
| Molecular Weight | 702.8 |
| PubChem CID | 102511306 |
| InChIKey | RIVAXSKTYGDAOA-NMIPJSAASA-N |
| Purity | >=99% (HPLC) |
储存条件
-20 C
技术属性
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Thymine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- None required
- Grade
- N (Normal)
- Packaging
- 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 25 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 2 years
应用背景
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- No base protection needed: thymine has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile DMT, removed each cycle).
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 102511306
PubChem · CID 102511306
常见问题
Why does the GNA-T amidite have no base protecting group?
Thymine has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile DMT group (removed each cycle) and the reactive phosphoramidite coupling group.
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