UNA-C(Ac) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C48H56N5O10P
- 分子量
- 894.0
- 纯度
- >=98.0% (HPLC)
UNA-C(Ac) CE Phosphoramidite is the unlocked nucleic acid (UNA) cytosine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N4-acetyl cytosine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65060 is identified by CAS 1120329-56-7, molecular formula C48H56N5O10P, molecular weight 894.0, PubChem CID 138376033, and InChIKey UMUWXRLDMCRCFS-GXOVKUNTSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
同义词
UNA-C(Ac) phosphoramidite; DMT-unlocked-N4-acetylcytidine CE phosphoramidite
身份与规格
| Catalog No. | CH65060 |
| CAS No. | 1120329-56-7 |
| Molecular Formula | C48H56N5O10P |
| Molecular Weight | 894.0 |
| PubChem CID | 138376033 |
| InChIKey | UMUWXRLDMCRCFS-GXOVKUNTSA-N |
| Purity | >=98.0% (HPLC) |
储存条件
-20 C
技术属性
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Cytosine
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- N4-acetyl
- Grade
- N (Normal)
- Packaging
- 10 mg; 50 mg; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; 5 kg; 10 kg; 25 kg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 3 years; in solvent 1 year
应用背景
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- 5'-DMT + N4-acetyl protection: the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 138376033
PubChem · CID 138376033
常见问题
How does it differ from the UNA-A(Bz) amidite?
Both are UNA (unlocked) phosphoramidites, but this one has an N4-acetyl-protected cytosine, whereas the UNA-A(Bz) amidite has an N6-benzoyl adenine. Each UNA base is cataloged separately.
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