UNA-G(iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C51H60N7O10P
- 分子量
- 962.0
- 纯度
- >=98.0% (HPLC)
UNA-G(iBu) CE Phosphoramidite is the unlocked nucleic acid (UNA) guanine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N2-isobutyryl guanine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65061 is identified by CAS 1120329-61-4, molecular formula C51H60N7O10P, molecular weight 962.0, PubChem CID 138376032, and InChIKey PCZJDFIZVYBABW-WESQYFQMSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
同义词
UNA-G(iBu) phosphoramidite; DMT-unlocked-N2-isobutyrylguanosine CE phosphoramidite
身份与规格
| Catalog No. | CH65061 |
| CAS No. | 1120329-61-4 |
| Molecular Formula | C51H60N7O10P |
| Molecular Weight | 962.0 |
| PubChem CID | 138376032 |
| InChIKey | PCZJDFIZVYBABW-WESQYFQMSA-N |
| Purity | >=98.0% (HPLC) |
储存条件
-20 C
技术属性
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- N2-isobutyryl
- Grade
- N (Normal)
- Packaging
- 10 mg; 50 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- powder 3 years; in solvent 1 year
应用背景
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 138376032
PubChem · CID 138376032
常见问题
How does it differ from the UNA-A(Bz) amidite?
Both are UNA (unlocked) phosphoramidites, but this one has an N2-isobutyryl-protected guanine, whereas the UNA-A(Bz) amidite has an N6-benzoyl adenine. Each UNA base is cataloged separately.
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