Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-FANA-adenosine

(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

产品编号CH70037CAS号20227-41-2纯度99.95%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: (2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
分子式: C10H12FN5O3
分子量: 269.23
纯度: 99.95%

2'-FANA-adenosine is a 2'F-ANA modified nucleoside: adenosine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 20227-41-2, molecular formula C10H12FN5O3, molecular weight 269.23, and PubChem CID 11065470.

The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70037 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.

同义词

2'-deoxy-2'-fluoro-arabino adenosine; 2'F-ANA adenosine

身份与规格

Catalog No.	CH70037
CAS No.	20227-41-2
Molecular Formula	C10H12FN5O3
Molecular Weight	269.23
Exact Mass	269.09241742
PubChem CID	11065470
InChIKey	ZGYYPTJWJBEXBC-GQTRHBFLSA-N
Purity	99.95%

储存条件

-20 C for powder; -80 C in solvent; protect from direct sunlight

技术属性

Material class: 2'F-ANA nucleoside
Nucleobase: Adenine
Sugar configuration: 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
Protection state: Unprotected
Packaging: 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 10 mM in DMSO, 1 mL; solid plus solvent kit for 10 mM in DMSO, 1 mL; Custom packaging on request
Solution concentration: 10 mM in DMSO
Physical form: White solid
Stability: 3 years at -20 C for powder; 1 year at -80 C in solvent

应用背景

2'F-ANA nucleoside reference: an adenosine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 11065470
PubChem · CID 11065470

常见问题

What is 2'-FANA-adenosine?

2'-FANA-adenosine is a 2'-deoxy-2'-fluoroarabino adenosine modified nucleoside. Its adenosine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 11065470.

How is 2'F-ANA different from ribo 2'-F-RNA?

Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.

Is CH70037 a phosphoramidite monomer?

No. CH70037 is documented as the modified nucleoside 2'-FANA-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.