Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-FANA-cytidine

4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

产品编号CH70038CAS号56632-83-8纯度>=98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: 4-amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
分子式: C9H12FN3O4
分子量: 245.21
纯度: >=98%

2'-FANA-cytidine is a 2'F-ANA modified nucleoside: cytidine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 56632-83-8, molecular formula C9H12FN3O4, molecular weight 245.21, and PubChem CID 151382.

The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70038 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.

同义词

2'-deoxy-2'-fluoro-arabino cytidine; 2'F-ANA cytidine

身份与规格

Catalog No.	CH70038
CAS No.	56632-83-8
Molecular Formula	C9H12FN3O4
Molecular Weight	245.21
Exact Mass	245.08118403
PubChem CID	151382
InChIKey	NVZFZMCNALTPBY-PXBUCIJWSA-N
Purity	>=98%

储存条件

-20 C for powder; -80 C in solvent

技术属性

Material class: 2'F-ANA nucleoside
Nucleobase: Cytosine
Sugar configuration: 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
Protection state: Unprotected
Grade: Research Chemical; reference standard for [18F]FAC
Packaging: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 10 mM, 1 mL; Custom packaging on request
Solution concentration: 10 mM; solvent not stated
Physical form: Solid
Stability: 3 years at -20 C for powder; 1 year at -80 C in solvent

应用背景

2'F-ANA nucleoside reference: a cytidine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Oligonucleotide chemistry context: use the 2'F-ANA class name and identifiers when matching research catalog records or confirmed internal specifications.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 151382
PubChem · CID 151382

常见问题

What is 2'-FANA-cytidine?

2'-FANA-cytidine is a 2'-deoxy-2'-fluoroarabino cytidine modified nucleoside. Its cytidine base and arabino-configured 2'-fluoro sugar are confirmed by PubChem CID 151382.

How is 2'F-ANA different from ribo 2'-F-RNA?

Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.

Is CH70038 a phosphoramidite monomer?

No. CH70038 is documented as the modified nucleoside 2'-FANA-cytidine. A protected CE phosphoramidite would require separate structural evidence and identifiers.