Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-FANA-guanosine

2-amino-9-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one

产品编号CH70039CAS号103884-98-6纯度99.45%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: 2-amino-9-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
分子式: C10H12FN5O4
分子量: 285.23
纯度: 99.45%

2'-FANA-guanosine is a 2'F-ANA modified nucleoside: guanosine attached to a 2'-deoxy-2'-fluoro-beta-D-arabinofuranose sugar. Key identifiers include CAS 103884-98-6, molecular formula C10H12FN5O4, molecular weight 285.23, and PubChem CID 135434940.

The 2'F-ANA family uses an arabino C2' configuration, which distinguishes it from ribo 2'-F-RNA. CH70039 should be presented as a modified nucleoside/reference compound for structure and catalog matching, not as a protected CE phosphoramidite monomer.

同义词

2'-deoxy-2'-fluoro-arabino guanosine; 2'F-ANA guanosine

身份与规格

Catalog No.	CH70039
CAS No.	103884-98-6
Molecular Formula	C10H12FN5O4
Molecular Weight	285.23
Exact Mass	285.08733204
PubChem CID	135434940
InChIKey	UXUZARPLRQRNNX-AYQXTPAHSA-N
Identity Note	PubChem maps CAS 103884-98-6 to multiple stereochemical records; this entry uses PubChem CID 135434940 for the FANA arabino configuration.
Purity	99.45%

储存条件

-20 C

技术属性

Material class: 2'F-ANA nucleoside
Nucleobase: Guanine
Sugar configuration: 2'-Deoxy-2'-fluoro-beta-D-arabinofuranose
Protection state: Unprotected
Packaging: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; Custom packaging on request
Physical form: White to off-white powder to crystals
Stability: 3 years at -20 C for powder; 1 year at -80 C in solvent

应用背景

2'F-ANA nucleoside reference: a guanosine-bearing 2'-deoxy-2'-fluoroarabino nucleoside for modified-nucleic-acid research.
Arabino 2'-fluoro chemistry: the arabino C2' configuration distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.
Oligonucleotide chemistry context: use the 2'F-ANA class name and verified identifiers when matching research catalog records or confirmed internal specifications.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 135434940
PubChem · CID 135434940

常见问题

What is 2'-FANA-guanosine?

2'-FANA-guanosine is a 2'-deoxy-2'-fluoroarabino guanosine modified nucleoside. PubChem maps the CAS to multiple stereochemical records; this page uses CID 135434940 for the FANA arabino configuration.

How is 2'F-ANA different from ribo 2'-F-RNA?

Both contain a 2'-fluoro sugar modification, but 2'F-ANA has the arabino configuration at C2'. That stereochemical difference distinguishes 2'F-ANA nucleosides from ribo 2'-F-RNA analogues.

Is CH70039 a phosphoramidite monomer?

No. CH70039 is documented as the modified nucleoside 2'-FANA-guanosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.