Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Propargyl-2-amino-adenosine

(2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol

产品编号CH70065CAS号1451256-04-4纯度>=95%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
分子式: C13H16N6O4
分子量: 320.30
纯度: >=95%

2'-O-Propargyl-2-amino-adenosine is a modified nucleoside with a 2,6-diaminopurine base and a 2'-O-propargyl sugar substituent. Key identifiers include CAS 1451256-04-4, molecular formula C13H16N6O4, molecular weight 320.30, and PubChem CID 102339225.

The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in clickable sugar-residue and click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.

同义词

2'-O-propargyl-2-aminoadenosine; 2'-O-propargyl-2,6-diaminopurine riboside

身份与规格

Catalog No.	CH70065
CAS No.	1451256-04-4
Molecular Formula	C13H16N6O4
Molecular Weight	320.30
Exact Mass	320.12330301
PubChem CID	102339225
InChIKey	AGYDCNMIAHDTSH-WOUKDFQISA-N
Structural Note	2,6-diaminopurine nucleoside with a 2'-O-propargyl sugar modification
Purity	>=95%

技术属性

Material class: 2'-O-propargyl nucleoside
Nucleobase: 2,6-Diaminopurine
Sugar modification: 2'-O-propargyl
Conjugation handle: Terminal alkyne
Packaging: Custom packaging on request

应用背景

Clickable sugar-residue research: literature reports 2'-O-propargylated 2-aminoadenosine in oligonucleotides with clickable sugar residues and bifunctional azide chemistry.
Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for click-compatible oligonucleotide research workflows.
Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl 2-aminoadenosine chemistry.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 102339225
PubChem · CID 102339225

常见问题

What is 2'-O-Propargyl-2-amino-adenosine?

It is a modified nucleoside: a 2,6-diaminopurine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 1451256-04-4 under stereospecific CID 102339225.

What does the propargyl group add?

The 2'-O-propargyl group provides a terminal alkyne handle, which is why this type of nucleoside appears in clickable sugar-residue and click-compatible oligonucleotide chemistry studies.

Is CH70065 a phosphoramidite monomer?

No. CH70065 is documented as the modified nucleoside 2'-O-Propargyl-2-amino-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.