Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Propargyl-adenosine

(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol

产品编号CH70066CAS号151390-97-5纯度98%

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
分子式: C13H15N5O4
分子量: 305.29
纯度: 98%

2'-O-Propargyl-adenosine is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 151390-97-5, molecular formula C13H15N5O4, molecular weight 305.29, and PubChem CID 22885207.

The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.

同义词

2'-O-propargyladenosine; 2'-O-propargyl adenosine

身份与规格

Catalog No.	CH70066
CAS No.	151390-97-5
Molecular Formula	C13H15N5O4
Molecular Weight	305.29
Exact Mass	305.11240398
PubChem CID	22885207
InChIKey	ROHGEAZREAFNTO-QYVSTXNMSA-N
Structural Note	Adenosine nucleoside with a 2'-O-propargyl sugar modification
Purity	98%

储存条件

-20 C for powder; -80 C in solvent

技术属性

Material class: 2'-O-propargyl nucleoside
Nucleobase: Adenine
Sugar modification: 2'-O-propargyl
Conjugation handle: Terminal alkyne
Grade: N (Normal)
Packaging: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; Custom packaging on request
Physical form: Solid
Stability: 3 years at -20 C for powder; 1 year at -80 C in solvent

应用背景

Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation and DNA click-modification contexts.
Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
Modified-nucleoside reference: use as a structure and identifier reference for 2'-O-propargyl adenosine chemistry.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 22885207
PubChem · CID 22885207

常见问题

What is 2'-O-Propargyl-adenosine?

It is a modified adenosine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 151390-97-5 under stereospecific CID 22885207.

What does the propargyl group add?

The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide chemistry contexts.

Is CH70066 a phosphoramidite monomer?

No. CH70066 is documented as the modified nucleoside 2'-O-Propargyl-adenosine. A protected CE phosphoramidite would require separate structural evidence and identifiers.