Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Propargyl-cytidine

4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one

产品编号CH70067CAS号206552-85-4纯度99% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidin-2-one
分子式: C12H15N3O5
分子量: 281.26
纯度: 99% (HPLC)

2'-O-Propargyl-cytidine is a modified cytidine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 206552-85-4, molecular formula C12H15N3O5, molecular weight 281.26, and PubChem CID 22885208.

The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.

同义词

2'-O-propargylcytidine; 2'-O-propargyl cytidine

身份与规格

Catalog No.	CH70067
CAS No.	206552-85-4
Molecular Formula	C12H15N3O5
Molecular Weight	281.26
Exact Mass	281.10117059
PubChem CID	22885208
InChIKey	FJGRSBJPLPTKDE-QCNRFFRDSA-N
Structural Note	Cytidine nucleoside with a 2'-O-propargyl sugar modification
Purity	99% (HPLC)

储存条件

10-25 C; cool dry and well ventilated

技术属性

Material class: 2'-O-propargyl nucleoside
Nucleobase: Cytosine
Sugar modification: 2'-O-propargyl
Conjugation handle: Terminal alkyne
Packaging: 10 mg; 25 mg; 50 mg; 100 mg; 1 g; 5 g; 10 g; 50 g; 100 g; 1 kg; Custom packaging on request
Physical form: Powder

应用背景

Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation and DNA click-modification contexts.
Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
Modified-cytidine reference: use as a structure and identifier reference for 2'-O-propargyl cytidine chemistry.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 22885208
PubChem · CID 22885208

常见问题

What is 2'-O-Propargyl-cytidine?

It is a modified cytidine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 206552-85-4 as CID 22885208.

What does the propargyl group add?

The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide chemistry contexts.

Is CH70067 a phosphoramidite monomer?

No. CH70067 is documented as the modified nucleoside 2'-O-Propargyl-cytidine. A protected CE phosphoramidite would require separate structural evidence and identifiers.