L-rA (Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C53H66N7O8PSi
- 分子量
- 988.2
- 纯度
- >=98.0% (HPLC)
L-rA (Bz) CE Phosphoramidite is a mirror-image RNA building block: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2'-O-(tert-butyldimethylsilyl)-L-adenosine 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. It is identified by CAS 1803193-36-3, molecular formula C53H66N7O8PSi, molecular weight 988.2, PubChem CID 13872239, and InChIKey FFXHNCNNHASXCT-XMSTWNTJSA-N.
It is the enantiomer of the natural D-adenosine amidite — built on L-ribose rather than D-ribose — so it has the same molecular formula and weight as its D-counterpart. The cited mirror-image oligonucleotide literature provides background for L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality. The 2'-O-TBDMS group protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N6-benzoyl base-protecting group is removed during final deprotection.
同义词
5'-O-DMT-N6-Bz-2'-O-TBDMS-L-adenosine 3'-CE phosphoramidite; L-riboadenosine (mirror-image) amidite
身份与规格
| Catalog No. | CH65086 |
| CAS No. | 1803193-36-3 |
| Molecular Formula | C53H66N7O8PSi |
| Molecular Weight | 988.2 |
| PubChem CID | 13872239 |
| InChIKey | FFXHNCNNHASXCT-XMSTWNTJSA-N |
| Purity | >=98.0% (HPLC) |
储存条件
2 to 8 C
技术属性
- Monomer class
- 2'-O-TBDMS L-RNA CE phosphoramidite
- Nucleobase
- Adenine
- Sugar configuration
- L-ribose
- Base protection
- N6-benzoyl
- Packaging
- 100 mg; 250 mg; 1 g; Custom packaging on request
- Physical form
- white to off-white powder
应用背景
- Mirror-image (L-ribose) monomer: provides the L-adenosine subunit identity for L-RNA synthesis.
- Mirror-image literature context: cited literature supports L-configured oligonucleotide chemistry and D/L strand-pairing orthogonality.
- RNA protection scheme: 2'-O-TBDMS protects the 2'-hydroxyl, the 5'-DMT is removed each cycle, and the N6-benzoyl base-protecting group is removed during final deprotection.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 13872239
PubChem · CID 13872239
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