CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

Spacer-C3 Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

产品编号CH65096CAS号110894-23-0纯度>=98.0% (HPLC)
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产品概述

快速信息

产品系列
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C33H43N2O5P
分子量
578.7
纯度
>=98.0% (HPLC)

Spacer-C3 Phosphoramidite is a non-nucleotide (abasic) spacer building block: a three-carbon (propyl) spacer carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 110894-23-0, molecular formula C33H43N2O5P, molecular weight 578.7, and PubChem CID 10303642.

Coupling inserts a non-nucleotide three-carbon spacer into the oligonucleotide backbone in place of a nucleotide — non-nucleotide chains can be incorporated into oligonucleotides this way (for example, to join segments or introduce a defined gap). The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.

同义词

DMT-O-C3-spacer 3'-CE phosphoramidite; 3-(DMTO)propyl non-nucleotide spacer amidite

身份与规格

Catalog No.CH65096
CAS No.110894-23-0
Molecular FormulaC33H43N2O5P
Molecular Weight578.7
PubChem CID10303642
InChIKeyIMRNWKAKFIGPOS-UHFFFAOYSA-N
Purity>=98.0% (HPLC)

储存条件

-20 C

技术属性

Reagent class
Non-nucleotide spacer phosphoramidite
Spacer type
Alkyl
Spacer length
3 carbons
End protection
5'-O-DMT
Grade
N (Normal)
Packaging
250 mg; 100 µmol; Custom packaging on request
Water content
<=0.5%
Physical form
colorless viscous oily liquid

应用背景

  • Non-nucleotide spacer insertion: introduces a three-carbon abasic spacer into the oligonucleotide backbone in place of a nucleotide.
  • Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
  • Backbone linker: non-nucleotide chains can be incorporated into oligonucleotides to join segments or introduce a defined gap.

相关技术资源

寡核苷酸修饰

用于 ASO、siRNA、guide RNA、适配体以及研究或标记项目的糖、碱基、骨架、末端和偶联修饰。

寡核苷酸合成

支持修饰单体、固相载体、硫化试剂、帽类似物和相关寡核苷酸合成输入物。

公开来源

常见问题

What is a spacer phosphoramidite?

It is a non-nucleotide (abasic) building block that inserts a spacer unit into the oligonucleotide backbone in place of a nucleotide. It couples through a 3'-phosphoramidite and carries a 5'-DMT (removed each cycle) so chain assembly continues normally.

What does the 'C3' mean?

C3 denotes the length of the spacer — a three-carbon (propyl) chain. Shorter (C2) and longer (C6, C12) variants and ethylene-glycol spacers give correspondingly different spacings.

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