Spacer-C12 Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
产品概述
快速信息
- 产品系列
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C42H61N2O5P
- 分子量
- 704.9
- 纯度
- >=98.0% (UPLC)
Spacer-C12 Phosphoramidite is a non-nucleotide (abasic) spacer building block: a twelve-carbon (dodecyl) spacer carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 158665-27-1, molecular formula C42H61N2O5P, molecular weight 704.9, and PubChem CID 67547892.
Coupling inserts a long non-nucleotide twelve-carbon spacer into the oligonucleotide backbone in place of a nucleotide — non-nucleotide chains can be incorporated into oligonucleotides this way (for example, to join segments or introduce a defined gap). The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.
同义词
DMT-O-C12-spacer 3'-CE phosphoramidite; 12-(DMTO)dodecyl non-nucleotide spacer amidite
身份与规格
| Catalog No. | CH65098 |
| CAS No. | 158665-27-1 |
| Molecular Formula | C42H61N2O5P |
| Molecular Weight | 704.9 |
| PubChem CID | 67547892 |
| InChIKey | QZFCUJPRTWVAIA-UHFFFAOYSA-N |
| Purity | >=98.0% (UPLC) |
储存条件
-20 C
技术属性
- Reagent class
- Non-nucleotide spacer phosphoramidite
- Spacer type
- Alkyl
- Spacer length
- 12 carbons
- End protection
- 5'-O-DMT
- Grade
- N (Normal)
- Packaging
- 250 mg; 500 mg; 1 g; 10 g; 100 g; 1 kg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless or light yellow oily liquid
应用背景
- Non-nucleotide spacer insertion: introduces a long twelve-carbon abasic spacer into the oligonucleotide backbone in place of a nucleotide.
- Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
- Backbone linker: non-nucleotide chains can be incorporated into oligonucleotides to join segments or introduce a defined gap.
相关技术资源
公开来源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 化合物 67547892
PubChem · CID 67547892
常见问题
What is a spacer phosphoramidite?
It is a non-nucleotide (abasic) building block that inserts a spacer unit into the oligonucleotide backbone in place of a nucleotide. It couples through a 3'-phosphoramidite and carries a 5'-DMT (removed each cycle) so chain assembly continues normally.
What does the 'C12' mean?
C12 denotes the length of the spacer — a twelve-carbon (dodecyl) chain, the longest alkyl spacer in this series. Shorter variants (C2, C3, C6) and ethylene-glycol spacers give correspondingly shorter or more polar spacings.
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