Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Propargyl-uridine

1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione

产品编号CH70070CAS号129778-58-1纯度99% (HPLC)

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产品概述

快速信息

产品系列: Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名称: 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]pyrimidine-2,4-dione
分子式: C12H14N2O6
分子量: 282.25
纯度: 99% (HPLC)

2'-O-Propargyl-uridine is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. Key identifiers include CAS 129778-58-1, molecular formula C12H14N2O6, molecular weight 282.25, and PubChem CID 15747441.

The 2'-O-propargyl group provides a terminal alkyne handle, placing this nucleoside in click-compatible oligonucleotide research contexts, including propargyl uridine-based RNA analogue chemistry. It should be presented as a modified nucleoside/reference compound, not as a protected CE phosphoramidite monomer.

同义词

2'-O-propargyluridine; 2'-O-propargyl uridine

身份与规格

Catalog No.	CH70070
CAS No.	129778-58-1
Molecular Formula	C12H14N2O6
Molecular Weight	282.25
Exact Mass	282.08518617
PubChem CID	15747441
InChIKey	SJIYVXTZWZSVLZ-QCNRFFRDSA-N
Structural Note	Uridine nucleoside with a 2'-O-propargyl sugar modification
Purity	99% (HPLC)

储存条件

<-15 C; keep container tightly closed

技术属性

Material class: 2'-O-propargyl nucleoside
Nucleobase: Uracil
Sugar modification: 2'-O-propargyl
Conjugation handle: Terminal alkyne
Grade: N (Normal)
Packaging: 5 mg; 10 mg; 25 mg; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; 10 kg; 25 kg; 50 kg; Custom packaging on request
Physical form: White powder

应用背景

Click-compatible oligonucleotide chemistry: 2'-O-propargyl nucleoside chemistry is reported in enzymatic oligonucleotide preparation, DNA click-modification, and propargyl uridine-based RNA analogue contexts.
Alkyne-handle nucleoside: the 2'-O-propargyl substituent provides a terminal alkyne handle for structure-aware click-chemistry research workflows.
Modified-uridine reference: use as a structure and identifier reference for 2'-O-propargyl uridine chemistry.

公开来源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem 化合物 15747441
PubChem · CID 15747441

常见问题

What is 2'-O-Propargyl-uridine?

It is a modified uridine nucleoside bearing a 2'-O-propargyl sugar substituent. PubChem confirms CAS 129778-58-1 as CID 15747441.

What does the propargyl group add?

The 2'-O-propargyl group provides a terminal alkyne handle, which places this type of nucleoside in click-compatible oligonucleotide and RNA analogue chemistry contexts.

Is CH70070 a phosphoramidite monomer?

No. CH70070 is documented as the modified nucleoside 2'-O-Propargyl-uridine. A protected CE phosphoramidite would require separate structural evidence and identifiers.