Bis-PEG6-NHS ester
化学名称
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Bis-PEG6-NHS ester•ADC linker
Structure: 
产品编号
CH53006
CAS
1526718-98-8
分子式
C24H36N2O14
分子量
576.55
规格标准
| Catalog No. | CH53006 |
| CAS No. | 1526718-98-8 |
| Molecular Formula | C24H36N2O14 |
| Molecular Weight | 576.55 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
Bis-PEG6-NHS ester (also known as (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate) (CAS 1526718-98-8, MF C24H36N2O14, MW 576.55) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. Custom synthesis, process scale-up and supply planning are available through CHEMOS R&D and manufacturing facilities.
应用
- Bis-PEG6-NHS ester (CAS 1526718-98-8) preparation, route refinement, and analytical-control planning
- Bioconjugation handle for site-specific cysteine / lysine attachment
- Cleavable peptide-linker design and intracellular-release studies
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs