N-Succinimidyl 6-maleimidohexanoate
化学名称
(2,5-dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate
N-Succinimidyl 6-maleimidohexanoate•ADC linker
Structure: 
产品编号
CH53016
CAS
55750-63-5
分子式
C14H16N2O6
分子量
308.29
规格标准
| Catalog No. | CH53016 |
| CAS No. | 55750-63-5 |
| Molecular Formula | C14H16N2O6 |
| Molecular Weight | 308.29 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
N-Succinimidyl 6-maleimidohexanoate (also known as (2,5-dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate) (CAS 55750-63-5, MF C14H16N2O6, MW 308.29) is an antibody-drug conjugate (ADC) linker or bioconjugation building block. Chemistry topics around such compounds typically cover the reactive handle (maleimide / NHS / DBCO / azide), linker stability in plasma, and release behaviour intracellularly. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- N-Succinimidyl 6-maleimidohexanoate (55750-63-5) as a starting point for downstream chemistry programs
- Antibody-drug conjugate (ADC) linker chemistry research
- Bioconjugation handle for site-specific cysteine / lysine attachment
- Cleavable peptide-linker design and intracellular-release studies