Mc-Val-Cit-PABC-PNP
化学名称
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
Mc-Val-Cit-PABC-PNP•ADC linker
Structure: 
产品编号
CH53018
CAS
159857-81-5
分子式
C35H43N7O11
分子量
737.76
规格标准
| Catalog No. | CH53018 |
| CAS No. | 159857-81-5 |
| Molecular Formula | C35H43N7O11 |
| Molecular Weight | 737.76 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
Mc-Val-Cit-PABC-PNP (also known as [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate) (CAS 159857-81-5, MF C35H43N7O11, MW 737.76) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.
应用
- Mc-Val-Cit-PABC-PNP (159857-81-5) as a starting point for downstream chemistry programs
- Bioconjugation handle for site-specific cysteine / lysine attachment
- Cleavable peptide-linker design and intracellular-release studies
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs